| Creators: |
Mihatsch, Walter A. and Von Schoenaich, Patrik and Fahnenstich, Hubert and Dehne, Norma and Ebbecke, Hartmut and Plath, Christian and Von Stockhausen, Hans-Burkhardt and Gaus, Wilhelm and Pohlandt, Frank |
| Title: |
Randomized, multicenter trial of two different formulas for very early enteral feeding advancement in extremely-low-birth-weight infants |
| Item Type: |
Article or issue of a publication series |
| Journal or Series Title: |
Journal of Pediatric Gastroenterology and Nutrition : JPGN |
| Page Range: |
pp. 155-159 |
| Date: |
2001 |
| Divisions: |
Gesundheitsmanagement |
| Abstract: |
Background:
In extremely-low-birth-weight (ELBW) infants, formula feeding is required if human milk is not available. The tolerance of a new 'high' lactose (55 g/L), low protein, low phosphate, hydrolyzed protein formula (HLF) for early enteral feeding advancement of ELBW infants was compared with that of a low lactose (1 g/L) hydrolyzed protein formula (LLF).
Methods:
In a randomized multicenter trial, 99 ELBW infants were fed according to a standardized protocol beginning at 48 hours of age with 12 ml/kg daily increments. Primary outcome was the cumulative milk feeding volume (CFV) from days 3 to 14. The authors hypothesized that feeding HLF as a supplement to human milk would increase the CFV at least by 20% in at least 60% of matched pairs compared with LLF. A secondary issue was to investigate whether human milk would increase the CFV compared with formula.
Results:
The CFV was 720 mL/kg (range, 0-962 mL/kg) with HLF and 613 mL/kg (range, 3-1,283 mL/kg) with LLF feeding. There was no 20% difference. On day 14, the median feeding volume was 103 mL/kg. The CFV was 533 mL/kg (range, 0-962 mL/kg) in infants who received less than 10% of human milk and 832 mL/kg (range, 74-1,283 mL/kg) in infants who received more than 10%. Necrotizing enterocolitis (Bell stage > or =2) occurred only with LLF feeding (n = 5; P < 0.05).
Conclusions:
The study failed to find the hypothesized 20% advantage of the new HLF. The observed advantage of human milk supports the hypothesis that it should be the first diet in ELBW infants; however, this hypothesis still must be confirmed in a controlled, randomized trial. |
| Forthcoming: |
No |
| Citation: |
Mihatsch, Walter A. and Von Schoenaich, Patrik and Fahnenstich, Hubert and Dehne, Norma and Ebbecke, Hartmut and Plath, Christian and Von Stockhausen, Hans-Burkhardt and Gaus, Wilhelm and Pohlandt, Frank
(2001)
Randomized, multicenter trial of two different formulas for very early enteral feeding advancement in extremely-low-birth-weight infants.
Journal of Pediatric Gastroenterology and Nutrition : JPGN, 33 (2).
pp. 155-159.
ISSN 0277-2116
|
