| Creators: |
Maier, Daniel and Vehreschild, Barbara and Meyer and Hadaschik, Boris and Palm, Stefan and Singer, Susanne and Stuschke, Martin and Juárez, David and Delpy, Pierre and Lambarki, Mohamed and Hummel, Michael and Engels, Cäcilia and Andreas, Stefanie and Gökbuget, Nicola and Ihrig, Kristina and Burock, Susen and Keune, Dietmar and Eggert, Angelika and Keilholz, Ulrich and Schulz, Hagen and Büttner, Daniel and Löck, Steffen and Krause, Mechthild and Esins, Mirko and Ressing, Frank and Schuler, Martin and Brandts, Christian and Brucker, Daniel P. and Husmann, Gabriele and Oellerich, Thomas and Metzger, Patrick and Voigt, Frederick and Illert, Anna L. and Theobald, Matthias and Kindler, Thomas and Sudhof, Ursula and Reckmann, Achim and Schwinghammer, Felix and Nasseh, Daniel and Weichert, Wilko and Von Bergwelt-Baildon, Michael and Bitzer, Michael and Malek, Nisar and Öner, Öznur and Schulze-Osthoff, Klaus and Bartels, Stefan and Haier, Jörg and Ammann, Raimund and Schmidt, Anja F. and Günther, Bernd and Janning, Melanie and Kasper, Bernd and Loges, Sonja and Stilgenbauer, Stephan and Kuhn, Peter and Tausch, Eugen and Runow, Silvana and Kerscher, Alexander and Neumann, Michael and Breu, Martin and Lablans, Martin and Serve, Hubert |
| Abstract (ENG): |
Treatment concepts in oncology are becoming increasingly personalized and diverse. Successively, changes in standards of care mandate continuous monitoring of patient pathways and clinical outcomes based on large, representative real-world data. The German Cancer Consortium’s (DKTK) Clinical Communication Platform (CCP) provides such opportunity. Connecting fourteen university hospital-based cancer centers, the CCP relies on a federated IT-infrastructure sourcing data from facility-based cancer registry units and biobanks. Federated analyses resulted in a cohort of 600,915 patients, out of which 232,991 were incident since 2013 and for which a comprehensive documentation is available. Next to demographic data (i.e., age at diagnosis: 2.0% 0–20 years, 8.3% 21–40 years, 30.9% 41–60 years, 50.1% 61–80 years, 8.8% 81+ years; and gender: 45.2% female, 54.7% male, 0.1% other) and diagnoses (five most frequent tumor origins: 22,523 prostate, 18,409 breast, 15,575 lung, 13,964 skin/malignant melanoma, 9005 brain), the cohort dataset contains information about therapeutic interventions and response assessments and is connected to 287,883 liquid and tissue biosamples. Focusing on diagnoses and therapy-sequences, showcase analyses of diagnosis-specific sub-cohorts (pancreas, larynx, kidney, thyroid gland) demonstrate the analytical opportunities offered by the cohort’s data. Due to its data granularity and size, the cohort is a potential catalyst for translational cancer research. It provides rapid access to comprehensive patient groups and may improve the understanding of the clinical course of various (even rare) malignancies. Therefore, the cohort may serve as a decisions-making tool for clinical trial design and contributes to the evaluation of scientific findings under real-world conditions. |
| Citation: |
Maier, Daniel and Vehreschild, Barbara and Meyer and Hadaschik, Boris and Palm, Stefan and Singer, Susanne and Stuschke, Martin and Juárez, David and Delpy, Pierre and Lambarki, Mohamed and Hummel, Michael and Engels, Cäcilia and Andreas, Stefanie and Gökbuget, Nicola and Ihrig, Kristina and Burock, Susen and Keune, Dietmar and Eggert, Angelika and Keilholz, Ulrich and Schulz, Hagen and Büttner, Daniel and Löck, Steffen and Krause, Mechthild and Esins, Mirko and Ressing, Frank and Schuler, Martin and Brandts, Christian and Brucker, Daniel P. and Husmann, Gabriele and Oellerich, Thomas and Metzger, Patrick and Voigt, Frederick and Illert, Anna L. and Theobald, Matthias and Kindler, Thomas and Sudhof, Ursula and Reckmann, Achim and Schwinghammer, Felix and Nasseh, Daniel and Weichert, Wilko and Von Bergwelt-Baildon, Michael and Bitzer, Michael and Malek, Nisar and Öner, Öznur and Schulze-Osthoff, Klaus and Bartels, Stefan and Haier, Jörg and Ammann, Raimund and Schmidt, Anja F. and Günther, Bernd and Janning, Melanie and Kasper, Bernd and Loges, Sonja and Stilgenbauer, Stephan and Kuhn, Peter and Tausch, Eugen and Runow, Silvana and Kerscher, Alexander and Neumann, Michael and Breu, Martin and Lablans, Martin and Serve, Hubert
(2023)
Profile of the multicenter cohort of the German Cancer Consortium’s Clinical Communication Platform.
European Journal of Epidemiology, 38 (5).
pp. 573-586.
ISSN 1573-7284
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